Mossy fiber sprouting interacts with sodium channel mutations to increase dentate gyrus excitability

EA Thomas; CA Reid; S Petrou

Journal article

Mossy fiber sprouting interacts with sodium channel mutations to increase dentate gyrus excitability

EA Thomas, CA Reid, S Petrou

Epilepsia | WILEY | Published : 2010

DOI: 10.1111/j.1528-1167.2009.02202.x

Abstract

Purpose: Idiopathic epilepsy is caused by the complex interaction of genetic and environmental factors. The purpose of this study was to use computational approaches to explore the interaction between changes in sodium channel availability caused by mutations and mossy fiber sprouting. Methods: We used a previously published biophysically realistic computer model of dentate gyrus neurons and networks. A sensitivity analysis probed the effects of typical mutation-like changes in either single- or multiple-gating parameters. Isolated neuron models were stimulated with current injections, and networks were stimulated with perforant path synaptic input. The gene-environment interaction was studi..

View full abstract

University of Melbourne Researchers

Evan Thomas Author

Christopher Reid Author

Related Projects (2)

Epilepsy: Molecular basis and mechanisms in the era of functional genomics

The team comprises of neurologists with a special interest in epilepsy (both adult and child) molecular geneticists, physiologists and brain..

Changes in the brain that cause epilepsy

About 100 000 people currently suffer from epilepsy in Australia and of these about one third are poorly controlled with current anti-epilep..

Grants

Awarded by Australian National Health and Medical Research Council

Funding Acknowledgements

[ "EAT was partially supported by an Australian National Health and Medical Research Council Peter Doherty Fellowship. CAR was supported by a University of Melbourne RD Wright Fellowship and by Australian National Health and Medical Research Council project grant 454655. Aspects of this work were also supported by an Australian National Health and Medical Research Council program grant 400121. We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.", "Disclosure: None of the authors has any conflict of interest to disclose." ]